Home › Quality & Science

Nitric Oxide Explained

The molecule behind healthy circulation.

Quick answer

Nitric oxide (NO) is a gas molecule made by the lining of blood vessels that signals the surrounding muscle to relax, widening vessels and supporting healthy blood flow. The body makes it in two main ways: the arginine pathway, where enzymes convert L-arginine (made from L-citrulline) into nitric oxide, and the nitrate pathway, where nitrates from foods like beets and leafy greens are converted into nitrite and then nitric oxide. Nitric oxide production tends to fall with age, smoking, high blood pressure, diabetes and inactivity. Exercise, nitrate-rich vegetables, citrulline-rich foods like watermelon, not smoking and avoiding antibacterial mouthwash overuse can help. Nitric oxide supporters may lower blood pressure and must not be combined with nitrate medicines.

Key takeaways

Nitric oxide is one of the most important molecules for circulation, and one of the most talked about in men's health.

What nitric oxide does

The endothelium, the thin lining of blood vessels, releases nitric oxide. It signals the smooth muscle around vessels to relax, so vessels widen and blood flows more freely. This is essential for healthy blood pressure, exercise and intimate health.

Two pathways

PathwayStarts withFood sources
Arginine pathwayL-arginine (and L-citrulline)Watermelon, nuts, meat, fish
Nitrate pathwayDietary nitratesBeets, arugula, spinach, celery

What lowers nitric oxide

How to support it naturally

  1. Exercise regularly
  2. Eat nitrate-rich vegetables daily
  3. Enjoy watermelon and other citrulline sources
  4. Don't smoke
  5. Eat flavonoid-rich foods like citrus and berries

Black Wood Tea supports both pathways with L-citrulline, L-arginine and beetroot, plus orange peel and tea antioxidants.

Safety: nitric oxide supporters can lower blood pressure. Never combine them with nitrate medicines such as nitroglycerin, and ask your doctor if you take ED or blood pressure medicines.

Sources

  1. Lundberg JO, et al. "The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics." Nature Reviews Drug Discovery, 2008.
  2. Harvard Health Publishing – "Nitric oxide and your health."
  3. Cormio L, et al. Urology, 2011 (L-citrulline).

Common questions

What is nitric oxide?

A molecule that helps blood vessels relax and widen.

How can I support nitric oxide naturally?

Exercise and eat nitrate-rich vegetables like beets and leafy greens.

Is it safe with heart medicines?

Never combine with nitrates; ask your doctor about other medicines.

← Back to home

↑